Raising Cannabis Capital 0041: InMed Pharmaceuticals

InMed Pharmaceuticals a publicly traded Canadian canna biopharmaceutical company CEO Eric Adams speak with Dan Humiston about their company's Biosynthesis research and their development of three canna drugs in their pipeline. 

Produced By MJBulls Media

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Dan Humiston:
Today Show and the following message are brought to you by a former guest. Alt 36 is a cannabis payment solution that's powered by Dash cryptocurrency. To learn how you can take part in their expansion go to all 36 dot com or listen to MJ bulls episode 12.

Eric Adams:
So what we've decided to do is come up with an alternative manufacturing process that will allow us to make all of these cannabinoids or any of these cannabinoids individually at a reasonable cost so that we can not only research them but we can build a commercial product around that.

Dan Humiston:
From Buminit media it's the MJBulls Podcast a show about Raising Cannabis Capital.

Dan Humiston:
I'm Dan Humiston and on today's show how. In med Pharmaceuticals is developing cannabinoid based medicine to help cure many debilitating illnesses.

Dan Humiston:
Today we're continuing our Raising Cannabis Capital series with Eric Adams the CEO of in med Pharmaceuticals which is a publicly traded Canadian biopharmaceutical company. Eric thanks for being on the MJBulls Podcast.

Eric Adams:
I appreciate the invitation.

Eric Adams:
Thanks for having me. Well it's universally accepted that cannabis has medicine and has the potential to cure just about every disease. I'm going to get a little technical for a minute here but I think this is really important one of the reasons that cannabis is so effective is that our bodies have a system called the ender cannabinoid system. Can you talk a little bit about the under cannabis. Just give us a brief overview of how it works and why it's so important. Sure.

Eric Adams:
Well the endo cannabinoid system is receptors that are located throughout the body and they're being found in most tissues. Most organs and the human body itself produces two cannabinoids and cannabinoids. So we make them ourselves. And these drugs that our body naturally makes regulates a number of things that regulates mood appetite pain a number of different things. What's interesting about these receptors is they also interact directly with cannabinoids or these. This class of compounds that can be found in nature and they're found in very high volumes of the cannabis plant. So the cannabis plant makes over 100 different chemicals called cannabinoids and these interact naturally with the human body. And that's why we're seeing so many diverse effects of cannabinoids and the cannabis plant treating disease in humans.

Dan Humiston:
I mean it's just fascinating that it's been there all along so the various combination of ratios of different cannabinoids have different impacts on the body is that how it works.

Eric Adams:
Well we believe so what we do know is that people who use cannabis can mitigate a lot of the symptoms of diseases that we see what's not fully understood is the role of each individual cannabinoid. So as I said there's over 100 of them. And that's really what matters setting now to do is to look at these individual drugs themselves and find out where they're best suited to treat diseases in the human body and what we're finding is that there are some exceptionally severe diseases that don't have any treatments right now where cannabinoids may play a very important role.

Dan Humiston:
And we're just now scratching the surface why see that in some cases it's just tiny tiny traces of the cannabinoid in combination with a number of different cannabinoids to create the impact on the patient that we'd hoped for. But to get a quantity of that trace element is really hard to do and I see on your website that you guys use it bio synthesis technique that you guys have developed. I think you need to explain this better than I. Because it's so interesting.

Eric Adams:
Yes. So we know that there's these hundred different cannabinoids when you take the marijuana plant and you extract out all these to have annoy you primarily to get THC and CBD and those to account for probably over 90 percent of the amount you can get at all the other cannabinoids these individual compounds are in very small amounts so small that you can't even really economically isolate the plants and then do any research on how these things can cost tens of thousands if not hundreds of thousands of dollars per gram if you try to isolate it from the plant. So what we've decided to do is come up with an alternative manufacturing process that will allow us to make all of these cannabinoids or any of these cannabinoids individually at a reasonable cost so that we can not only research them but we can build a commercial product around that. And so that's what bio synthesis is. If you start with the plants the plant has a number of different genes that will say OK this gene will tell the plant to make this cannabinoid Well what we're doing is we're taking that same gene and we're putting it into bacteria and we've come up with a way to manipulate the bacteria so that it can produce cannabinoids the same way the plant would produce cannabinoids. And that's a big part of our technology is kind of unlocking the ability to access these cannabinoids and then further research them into individual diseases.

Eric Adams:
That is just fascinating. So you'll be able to produce large quantities of otherwise nearly impossible traces of these really small doses of cannabinoids using this process.

Eric Adams:
That's the game plan. So we still have that process in development. We're now headed towards what we call commercial scale up where we've proven at a small scale. Now we need to use industrial size equipment to be able to make vast quantities of these things at a very low cost. And so we're in the process of going through that scale of exercise.

Dan Humiston:
Now. Just a quick shout out to one of our former guest. Autocure Automated drawing and curing units that are being installed in large cannabis cultivation facilities throughout North America. Listen to MJBulls Episode 7 record autocure.us to find out how you can invest in their expansion. And now back to the show.

Dan Humiston:
Well you also have drugs that you have in the pipeline. I think these are really interesting. These drugs maybe you could talk about each of the drugs and what they're for and how far along you are with each of these drugs.

Eric Adams:
Sure. So in my head is based on a couple of principles. First of all we don't use any THC in our product. Now THC has a lot of effects on the human body. But it also has the side effect of getting you high. And we think that that's a negative side effect for patients who really just want their disease is treated. So no one no THC. Secondly we are a topical company so we are delivering the cannabinoids specifically to the side of disease. We think if we do that we can use a very small amount and minimize any systemic side effects that you might see from using these drugs. We're looking at things like the creams for the skin and eye drops for the eye to treat various diseases and there's a plethora of diseases that we can start to address with that approach. OK. So what we've done is we've identified a couple of cannabinoids of interest that we think have a high potential to treat a number of diseases that currently don't have any alternatives. The first one that we have is the name of the drug is and hemp 750 it is a combination of two cannabinoids that is directed towards treating a rare genetic absolutely horrible skin disease called epidermal ices below. So this is also referred to as the butterfly child syndrome because the skin is so fragile that it just can fall off and cause large open wounds over big areas of the body. It's absolutely devastating and currently there is no approved products for that. And what we've learned about cannabinoids is they can do a couple of interesting things. First of all from a symptom standpoint what are the symptoms of this disease that need to be treated on a daily or every other day basis.

Eric Adams:
You need to accelerate the wound healing. You need to reduce pain. You need to reduce the itch which is often worse than the pain. You need to reduce inflammation and you need to give some kind of antibacterial coverage to prevent infection. Well it turns out cannabinoids can do all of those things if you select the right ones. You can do all five of those things. And so we think from a symptom standpoint we can help these patients a great deal with one product. They can do all those things. The other side of the equation is disease itself. Now this is a genetic disease so in Russia you come up with a gene therapy to correct those genes you aren't going to cure quote unquote the disease but we think we can mitigate the disease and potentially see some reversal. What we've learned about cannabinoids is they up regulate and down regulate these proteins that are found throughout the body called charities. And one form of Eby is related to a keratin that is genetically malformed. We can't correct that. But what we can do is we can increase the production in the body of a keratin that may be able to replace the one that's damaged. So in effect seeing some disease reversal by the body kind of finding a way to heal itself. And we know that can we know that cannabinoids can increase or decrease certain of these proteins called keratin. So that's a very unique approach and that's something that we're very excited.

Dan Humiston:
Well I saw the photographs of some of the people with this illness and it's just horrifying.

Dan Humiston:
I can't imagine there's a lunatic fantasy. Yes. But the other two drugs that you're working on.

Eric Adams:
Sure. So we have a another drug candidate called I announce 0 8 5. This is a cannabinoid that's targeting glaucoma. You know there's a lot of anecdotal evidence of people who smoke marijuana are able to relieve the pain and pressure of glaucoma glaucoma. I think the second leading cause of blindness of adults for a host of reasons but we think it's a very interesting approach we think that cannabinoids will have some unique benefits in treating this disease. And so we not only are pursuing cannabinoids for that we've also developed a once a day eyedrops think is unique and should be able to increase the amount of drugs that is able to affect the eye. So we're very excited about that program as well. What about behind 750 the 750 products for TB. We're targeting to be in human clinical trials in the second half of 2019 and we're on track to do that. So glaucoma a little bit farther behind that. And then we have a third product and for our side and this is for pain would come as no surprise to most people that cannabinoids can treat pain.

Eric Adams:
And again you go back to people who smoke marijuana to relieve pain. We're looking at a specific cannabinoid a non THC cannabinoid that can have the same kinds of the facts that THC does just without getting the patient. Again we're looking at a topical approach. So it'll be a skin cream and in particular we're looking. Things that are related to migraines very severe pain that currently that the treatments just aren't sufficient for and to see people who suffer from migraines you see them massaging their temples to try and relieve that. Well there is a nerve right there just below the skin that is responsible for all of the nerve endings in the face. So for people who suffer any kind of job pain or tooth pain or what have you you can access that nerve with a topical cream and hopefully mitigates not only common pain but also more severe forms of pain so in men it's a publicly traded company right now and you're on the Toronto Stock Exchange and the Yo T CQ.

Eric Adams:
What are your stock symbols in Canada

Dan Humiston:
Well we're going to have all the information from in med pharmaceuticals and the MJBulls website. Eric is really appreciate you taking the time to talk to us today.

Eric Adams:
Absolutely. And again I think there's a lot of companies out there who are starting to explore these kinds of applications of cannabinoids and part of what we're trying to do with the bio synthesis program is enable other people as well to access any of these hundred cannabinoids that they think might work for a specific disease. You know someone's got to be able to make those and provide other people.

Eric Adams:
So if we can arrange some kind of licensing agreement with other companies we think it's going to just lift the whole field and that you'll see a lot more companies like ours looking at a very broad array of different diseases in the not too distant future.

Dan Humiston:
This has to be a community effort. There's just too many just too many pieces that his puzzle for any one group to take it on themselves.

Dan Humiston:
Well I appreciate everything you're doing Eric. Thank you again for being on the show.

Eric Adams:
Nice talking with you.

Dan Humiston:
Thank you so much. Just a quick shout out to one of our former guest cliintel Capital Management Group he cannabis investment fund with diverse investments throughout all sectors of the cannabis industry. Listen to MJBulls Episode 24. Go to cliintelcapital.com to find out how you can invest in one of their funds.

Dan Humiston:
Thanks for listening to the MJBulls Podcast. To learn more about today's guests poor to become a guest. Visit our Web site at MJBulls.com.

Today's show is produced by Buminit media with original music composed by Jamie Humiston hemp Dan Humiston and you've been listening to the MJBulls Podcast.

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